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Quantitative 1 H magnetization transfer imaging in vivo
Author(s) -
Eng John,
Ceckler Toni L.,
Balaban Robert S.
Publication year - 1991
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910170203
Subject(s) - magnetization transfer , magnetization , relaxation (psychology) , spin–lattice relaxation , nuclear magnetic resonance , saturation (graph theory) , chemistry , proton , materials science , magnetic field , physics , magnetic resonance imaging , biology , medicine , mathematics , quantum mechanics , combinatorics , neuroscience , nuclear quadrupole resonance , radiology
A major factor contributing to proton ( 1 H) spin‐lattice relaxation in biological tissues is believed to be magnetization transfer between 'H in free bulk water and 1 H in restricted motion associated with macromolecules. We have shown recently that saturation transfer is an effective approach for studying this magnetization transfer process. Herein the determination of magnetization transfer rates in biological tissues is further analyzed by considering the time and power dependencies of saturation transfer. Following these analyses, quantitative magnetization transfer rate constant image maps were collected from the kidney in vivo. These rate constant images may prove useful in quantitative tissue characterization and in the determination of tissue‐specific 1 H relaxation mechanisms. © 1991 Academic Press, Inc.