Application of volume‐selected, two‐dimensional multiple‐quantum editing  in vivo  to observe cerebral metabolites | Zendy

Crozier Stuart | Zendy; Brereton Ian M. | Zendy; Rose Stephen E. | Zendy; Field James | Zendy; Shan Gerald F. | Zendy; Doddrell David M. | Zendy

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Application of volume‐selected, two‐dimensional multiple‐quantum editing in vivo to observe cerebral metabolites

Author(s) -

Crozier Stuart,

Brereton Ian M.,

Rose Stephen E.,

Field James,

Shan Gerald F.,

Doddrell David M.

Publication year - 1990

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910160317

Subject(s) - glutamine , in vivo , volume (thermodynamics) , relaxation (psychology) , cerebral blood volume , sequence (biology) , quantum , nuclear magnetic resonance , signal (programming language) , glutamate receptor , chemistry , biophysics , physics , computer science , neuroscience , biology , cerebral blood flow , biochemistry , quantum mechanics , amino acid , medicine , genetics , receptor , programming language , cardiology

The volume selection technique SPACE has been combined with a two‐dimensional multiple‐quantum editing sequence to uniquely detect certain J‐coupled cerebral metabolites. In vivo results demonstrating edited glutamate/glutamine and lactate from 0.4 ml of a rat's brain at 4.7 T are presented. The sequence was optimized to balance multiple‐quantum generation and signal loss due to T 2 relaxation. Without due regard to T 2 relaxation little signal is observed. © 1990 Academic Press, Inc.

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