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Application of volume‐selected, two‐dimensional multiple‐quantum editing in vivo to observe cerebral metabolites
Author(s) -
Crozier Stuart,
Brereton Ian M.,
Rose Stephen E.,
Field James,
Shan Gerald F.,
Doddrell David M.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910160317
Subject(s) - glutamine , in vivo , volume (thermodynamics) , relaxation (psychology) , cerebral blood volume , sequence (biology) , quantum , nuclear magnetic resonance , signal (programming language) , glutamate receptor , chemistry , biophysics , physics , computer science , neuroscience , biology , cerebral blood flow , biochemistry , quantum mechanics , amino acid , medicine , genetics , receptor , programming language , cardiology
The volume selection technique SPACE has been combined with a two‐dimensional multiple‐quantum editing sequence to uniquely detect certain J‐coupled cerebral metabolites. In vivo results demonstrating edited glutamate/glutamine and lactate from 0.4 ml of a rat's brain at 4.7 T are presented. The sequence was optimized to balance multiple‐quantum generation and signal loss due to T 2 relaxation. Without due regard to T 2 relaxation little signal is observed. © 1990 Academic Press, Inc.