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In vivo volume‐selective metabolite editing via correlated z ‐order
Author(s) -
Brereton Ian M.,
Rose Stephen E.,
Galloway Graham J.,
Moxon Leith N.,
Doddrell David M.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910160312
Subject(s) - metabolite , in vivo , volume (thermodynamics) , chemistry , order (exchange) , nuclear magnetic resonance , biology , physics , biochemistry , genetics , thermodynamics , finance , economics
Volume‐selected 1 H NMR spectroscopy was combined with spectral editing to selectively detect brain metabolites. The SPACE localization sequence was used to create a voxel of z‐magnetization which could then be edited for any scalar coupled metabolite by the use of selective excitation in the ECZOTIC sequence to generate longitudinal spin order. The sequence returns an edited signal with no intrinsic loss of magnetization. The method was applied to observe approximately 10 m M ethanol and 17 m M lactate in the brain of a dog. © 1990 Academic Press, Inc.