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Direct carbon versus proton heteronuclear editing of 2‐ 13 C ethanol in rabbit brain in vivo : A sensitivity comparison
Author(s) -
Novotny Edward J.,
Ogino Takashi,
Rothman Douglas L.,
Petroff Ognen A. C.,
Prichard James W.,
Shulman Robert G.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910160310
Subject(s) - heteronuclear molecule , in vivo , chemistry , proton , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , ethanol , spectroscopy , resolution (logic) , proton nmr , stereochemistry , biochemistry , physics , biology , nuclear physics , microbiology and biotechnology , quantum mechanics , artificial intelligence , computer science
Proton NMR editing techniques were utilized to study the pharmacology of 13 C‐labeled ethanol in the cerebrum of the living rabbit at 4.7 T. The sensitivity of these proton spectroscopic methods was compared to direct carbon spectroscopy and a 14‐fold improvement in sensitivity of 1 H over 13 C NMR spectroscopy was observed in vivo. This increase in sensitivity permitted the observation of the time course of the influx and afflux of this 13 C‐labeled compound with a time resolution of approximately 2 min per spectrum. © 1990 Academic Press, Inc.