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An ESR study of pathologic red blood cell membranes (RBCM)
Author(s) -
Perussi Janice R.,
Costa Fernando F.,
Baffa Oswaldo,
Zago Marco A.,
Tintoand Maria H.,
Tabak Marcel
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910160112
Subject(s) - membrane , sickle cell anemia , red blood cell , thalassemia , spin label , chemistry , stearic acid , cell , red cell , nuclear magnetic resonance , biochemistry , medicine , physics , organic chemistry
A comparative study of red blood cell membranes from normal subjects and β‐thalassemia and sickle cell anemia patients was performed by spin labeling at the lipidic and protein phase. The results show that the quantity of bound spin label is the same for sickle, thalassemic, and normal membranes. The data from 5‐doxyl stearic acid suggest an increase in fluidity for the thalassemic membrane. © 1990 Academic Press, Inc.