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Development of the “activated” high resolution 1 H MR spectrum in murine T cells and B cells occurs in G 1 phase of the cell cycle
Author(s) -
Holmes K. T.,
Lean C. L.,
Hunt N. H.,
King N. J. C.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910160102
Subject(s) - cell cycle progression , cell cycle , high resolution , phase (matter) , resolution (logic) , isotropy , b cell , cell growth , chemistry , cell , microbiology and biotechnology , biology , physics , antibody , biochemistry , immunology , optics , computer science , remote sensing , organic chemistry , geology , artificial intelligence
T and B lymphocytes stimulated with mitogens develop 'HMR spectra characteristic of triglycerides in an isotropic environment. These distinctive signals, which are also observed in malignant cells, cannot be suppressed by compounds which inhibit progression through the cell cycle. Cellular proliferation is thus not essential for the development and maintenance of high resolution lipid spectra in activated cells. © 1990 Academic Press, Inc.