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In Vivo NMR spectroscopy of lithium‐7 in humans
Author(s) -
Komoroski R. A.,
Newton J. E. O.,
Walker E.,
Cardwell D.,
Jagannathan N. R.,
Ramaprasad S.,
Sprig J.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910150302
Subject(s) - in vivo , lithium (medication) , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , spectroscopy , magnetic resonance imaging , chemistry , nuclear medicine , medicine , biology , radiology , physics , microbiology and biotechnology , quantum mechanics
The pharmacokinetics of lithium uptake was measured by 7 Li NMR spectroscopy at 24.83 MHz in vivo in the brain and muscle of a normal subject and a patient suffering from bipolar affective disorder, using a modified General Electric Signa clinical magnetic resonance imaging system. Comparison was made to standard phantoms to estimate Li concentrations. The levels of Li in brain and muscle were similar, were typically less than the level in serum, and generally tracked the level in serum. The Li level at steady state in the brain of a patient suffering from schizoaffective disorder was measured over a 7‐month period. Substantial variation was seen, which showed some correlation with serum level. Serum level peaked about 2 h after a single 300‐mg dose at steady state, and muscle level, immediately thereafter. Brain level peaked considerably later at 4 h. Localized in vivo 7 Li NMR spectroscopy was demonstrated by acquisition of a 125‐cm 3 DRESS slice from the occipital region in less than 7 min. © 1990 Academic Press, Inc.