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T 2 of endotoxin lung injury with and without methylprednisolone treatment
Author(s) -
Shioya Sumie,
Haida Munetaka,
Tsuji Chizuko,
Ono Yoshiaki,
Miyairi Akira,
Fukuzaki Minoru,
Ohta Yasuyo,
Yamabayashi Hajime
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910150204
Subject(s) - methylprednisolone , lung , medicine , relaxation (psychology) , lung function , nuclear medicine , anesthesia , gastroenterology , pathology
NMR relaxation times ( T 1 and T 2 ) and the water content (WC) of in vitro rat lungs were measured during the course of endotoxin lung injury in rats. Measurements of normal lungs, untreated endotoxin‐injured lungs, and endotoxin‐injured lungs treated with methylprednisolone (MPSL) were compared. The untreated endotoxin lungs showed prolongation of the fast and slow T 2 components ( T 2r and T 2s ), but no significant changes in T 1 or water content. Also, there was no correlation between 1 /WC and relaxation rates or between T 1 and T 2 . MPSL treatment prevented T 2f and T 2s prolongation; however, the duration of MPSL effectiveness was limited. Animals which were treated with MPSL more than 7 h prior to measurements showed T 2 prolongation. This study indicates that NMR relaxation times, particularly T 2 , can be useful in evaluating lung injuries and their treatments. © 1990 Academic Press, Inc.