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Is the detection of fucose cancer markers by 2D 1 H NMR unequivocal?
Author(s) -
Phillips P. S.,
Herring F. G.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910150102
Subject(s) - fucose , pulse sequence , nuclear magnetic resonance , chemistry , proton nmr , cancer , biochemistry , biology , stereochemistry , physics , genetics , glycoprotein
Fucose is believed to be a marker for cancer that may be detectable by the 2D proton NMR (COSY) of human plasma. However, the COSY technique is time consuming and prone to error. These problems may be alleviated by using the SUPERCOSY pulse sequence; this technique shows that there are many other cross peaks in the region (1.3, 4.2 ppm) which are not readily distinguishable from fucose. © 1990 Academic Press, Inc.