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Functional cerebral imaging by susceptibility‐contrast NMR
Author(s) -
Belliveau John W.,
Rosen Bruce R.,
Kantor Howard L.,
Rzedzian Richard R.,
Kennedy David N.,
McKinstry Robert C.,
Vevea James M.,
Cohen Mark S.,
Pykett Ian L.,
Brady Thomas J.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910140311
Subject(s) - nuclear magnetic resonance , susceptibility weighted imaging , magnetic resonance imaging , hypercapnia , image contrast , in vivo , contrast (vision) , chemistry , medicine , biology , anatomy , radiology , physics , respiratory system , optics , microbiology and biotechnology
In vivo measurement of cerebral physiology by dynamic contrast‐enhanced NMR is demonstrated. Time‐resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility‐induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured. © 1990 Academic Press, Inc.