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Magnetic resonance imaging of experimental demyelinating lesions
Author(s) -
Ford Corey C.,
Ceckler Toni L.,
Karp Juliana,
Herndon Robert M.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910140305
Subject(s) - lysophosphatidylcholine , magnetic resonance imaging , myelin , remyelination , pathology , lesion , nuclear magnetic resonance , histopathology , medicine , white matter , spin echo , edema , central nervous system , chemistry , radiology , physics , phospholipid , biochemistry , membrane , phosphatidylcholine , psychiatry , endocrinology
An animal model of central nervous system demyelination was created by injecting rat internal capsules with lysophosphatidylcholine (LPC). The resulting chemically induced demyelinating lesions were readily visible in T 1 ‐weighted spin‐echo, T 2 weighted spin‐echo, and inversion‐recovery magnetic resonance imaging (MRI) sequences. Changes in lesions were followed over 8 weeks and correlated with histopathology. Histologically, lesions were characterized initially by an acute, inflammatory phase with edema and blood‐brain barrier breakdown, followed by macrophage‐mediated removal of myelin debris and finally by remyelination after 3 to 4 weeks. MRI can differentiate lesion stages in the LPC model and may be useful in investigating mechanistic aspects of the demyelinating process. In addition the well‐localized lesions may be amenable to study by techniques of volume‐localized NMR Spectroscopy. © 1990 Academic Press, Inc.