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Measurement of regional cerebral blood flow in cat brain using intracarotid 2 H 2 O and 2 H NMR imaging
Author(s) -
Detre J. A.,
Subramanian V. H.,
Mitchell M. D.,
Smith D. S.,
Kobayashi A.,
Zaman A.,
Leigh J. S.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910140223
Subject(s) - cerebral blood flow , nuclear magnetic resonance , blood flow , cerebrovascular circulation , flow (mathematics) , chemistry , nuclear medicine , physics , medicine , radiology , mechanics
Cerebral blood flow (CBF) was measured in cat brain in vivo at 2.7 T using 2 H NMR to monitor the washout of deuterated saline injected into both carotid arteries via the lingual arteries. In anesthetized cats, global CBF varied directly with P aCO 2 over a range of 20‐50 mm Hg, and the corresponding global CBF values ranged from 25 to 125 ml‐100 g −1 min −1 . Regional CBF was measured in a 1‐cm axial section of cat brain using intracarotid deuterated saline and gradient‐echo 2 H NMR imaging. Blood flow images with a maximum pixel resolution of 0.3 × 0.3 × 1.0 cm were generated from the deuterium signal washout at each pixel. Image derived values for CBF agreed well with other determinations, and decreased significantly with hypocapnia. © 1990 Academic Press, Inc.