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Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease
Author(s) -
Arnold Douglas L.,
Matthews Paul M.,
Francis Gordon,
Antel Jack
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910140115
Subject(s) - creatine , multiple sclerosis , nuclear magnetic resonance , magnetic resonance imaging , proton magnetic resonance , metabolite , proton , medicine , in vivo , nuclear magnetic resonance spectroscopy , central nervous system disease , functional magnetic resonance spectroscopy of the brain , nuclear medicine , chemistry , pathology , radiology , physics , biology , microbiology and biotechnology , quantum mechanics , psychiatry
Image localized, water‐suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N ‐acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury. © 1990 Academic Press, Inc.