Proton magnetic resonance spectroscopy of human brain  in vivo  in the evaluation of multiple sclerosis: Assessment of the load of disease | Zendy

Arnold Douglas L. | Zendy; Matthews Paul M. | Zendy; Francis Gordon | Zendy; Antel Jack | Zendy

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Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease

Author(s) -

Arnold Douglas L.,

Matthews Paul M.,

Francis Gordon,

Antel Jack

Publication year - 1990

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910140115

Subject(s) - creatine , multiple sclerosis , nuclear magnetic resonance , magnetic resonance imaging , proton magnetic resonance , metabolite , proton , medicine , in vivo , nuclear magnetic resonance spectroscopy , central nervous system disease , functional magnetic resonance spectroscopy of the brain , nuclear medicine , chemistry , pathology , radiology , physics , biology , microbiology and biotechnology , quantum mechanics , psychiatry

Image localized, water‐suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N ‐acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury. © 1990 Academic Press, Inc.

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