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Assessment of a superparamagnetic iron oxide (ami‐25) as a brain contrast agent
Author(s) -
Kent Thomas A.,
Quast Michael J.,
Kaplan Barry J.,
Lifsey Robert S.,
Eisenberg Howard M.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130310
Subject(s) - perfusion , white matter , contrast (vision) , mri contrast agent , cerebrospinal fluid , perfusion scanning , magnetic resonance imaging , ischemia , medicine , nuclear medicine , nuclear magnetic resonance , pathology , chemistry , radiology , cardiology , computer science , physics , artificial intelligence
We have applied a superparamagnetic iron oxide formulation (AMI‐25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast‐enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities. © 1990 Academic Press, Inc.