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In situ assessment of tumor vascularity using fluorine nmr imaging
Author(s) -
Ceckler Toni L.,
Gibson Scott L.,
Hilf Russell,
Bryant Robert G.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130309
Subject(s) - in situ , vascularity , fluorine 19 nmr , nuclear magnetic resonance , magnetic resonance imaging , medical physics , chemistry , medicine , nuclear medicine , nuclear magnetic resonance spectroscopy , radiology , physics , organic chemistry
In situ fluorine NMR imaging has been used to measure vascularity in subcutancously implanted mammary tumors. Oxyferol, a perfluorinated blood substitute comprised of an emulsion of 25% w/v perfluorotributylamine, was used as a tracer. Following iv administration, this perfluorocarbon emulsion remains primarily in the vasculature during the image acquisition period. The distribution of the PFTA in the 19 F NMR image gives a map of tissue regions with intact vascularity. This technique has been used to demonstrate decreased blood flow in necrotic regions of R3230AC mammary tumors in which vasculature had been damaged either as a result of spontaneous necrosis or by photodynamic therapy (PDT). Damage to tumor vascularity following PDT was observed prior to the development of necrosis.