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Mri quantitation of edema in focal cerebral ischemia in cats: correlation with cytochrome aa 3 oxidation state
Author(s) -
Kline R. A.,
Negendank W. G.,
Mccoy L. E.,
Lester M.,
Berguer R.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130215
Subject(s) - ischemia , edema , cats , stroke (engine) , in vivo , brain ischemia , medicine , cerebral edema , middle cerebral artery , chemistry , magnetic resonance imaging , pathology , nuclear medicine , anesthesia , cardiology , radiology , biology , mechanical engineering , microbiology and biotechnology , engineering
1 H MRI permits detection of edema in the brain. In a middle cerebral artery stroke model in the cat, we found a significant correlation between an edema index based on MRI and a sensitive metabolic index of ischemia, the in vivo oxidation status of mito‐chondrial cytochrome aa 3 determined by near‐infrared reflectance spectrophotometry ( r= −0.70, α = 0.001). This result suggests that a simple, noninvasive study using MRI can provide an index of the extent of ischemic damage in an experimental acute stroke model.