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Triple‐quantum‐coherence‐filtered imaging of sodium ions in vivo at 4.7 tesla
Author(s) -
Griffey Richard H.,
Griffey Beatrice V.,
Matwiyoff Nicholas A.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130213
Subject(s) - ion , sodium , coherence (philosophical gambling strategy) , in vivo , chemistry , nuclear magnetic resonance , physics , microbiology and biotechnology , organic chemistry , quantum mechanics , biology
Abstract The tissue distribution of sodium ions which generate triple‐quantum coherence (TQC) in vivo is determined from images. A technique for filtering conventional sodium images, so that signal is obtained only from sodium ions which have a correlation time appropriate for producing TQC, is described. The utility of TQC‐filtered sodium images is demonstrated in a study of tumors implanted in a nude rat model, where the intensity of the TQC signal from sodium ions in the growing margin of the tumor is observed to be 200‐250% greater than that from surrounding tissue.