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Epicardial and endocardia1 localized 31 p magnetic resonance spectroscopy: evidence for metabolic heterogeneity during regional ischemia
Author(s) -
Gober Joel R.,
Schaefer Saul,
Albert Camacho S.,
Degroot Michael,
Obregon Richard,
Botvinick Elias H.,
Weiner Michael,
Massie Barry
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130204
Subject(s) - endocardium , phosphocreatine , ischemia , nuclear magnetic resonance , blood flow , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , spectroscopy , high energy phosphate , chemistry , medicine , materials science , energy metabolism , radiology , physics , quantum mechanics
Previous studies have noted that myocardial blood flow and high energy phosphates are heterogeneous across the myocardial wall during ischemia. In order to determine whether differences in metabolites between the subendocardium and subepicardium could be detected using 31 P magnetic resonance spectroscopy, the Fourier series window (FSW) experiment was implemented on a porcine model of graded regional ischemia. FSW experiments using a planar phantom showed a 46% improvement in localization to the subendocardium compared to a one‐pulse experiment. Animal studies of graded ischemia demonstrated a gradient in the phosphocreatine to inorganic phosphate ratio in the myocardium that paralleled the gradient in blood flow. These studies demonstrate the ability of spatially localized 31 P magnetic resonance spectroscopy to detect regional changes in myocardial high energy phosphates localized to the subepicardium and subendocardium.