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Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1 h nmr spectroscopic imaging
Author(s) -
Segebarth Christoph M.,
Balériaux Danielle F.,
Luyten Peter R.,
Den Hollander Jan A.
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130108
Subject(s) - in vivo , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , chemistry , biology , microbiology and biotechnology , physics
Patients with intracranial tumors (gliomas) were examined by means of localized water‐suppressed 1 H NMR single volume spectroscopy and spectroscopic imaging. The 1 H NMR spectra of the tumors exhibit signal intensities of the N‐acetyl aspartate, choline compounds, and creatine plus phosphocreatine resonance lines that are different from the corresponding intensities observed on normal brain tissue. Also, for 6 out of the 10 patients examined so far, lactate resonance lines were detected in the tumor spectra. For one patient, abnormal 1 H NMR spectra were obtained of a hemisphere which appeared normal with 1 H NMR imaging. Metabolic heterogeneity of the tumorous regions could be demonstrated with 1 H NMR spectroscopic imaging, using a spatial resolution in the order of 1 cm. These results suggest a spectrum of metabolic observations that may ultimately provide an important means for characterizing brain tumors.