Design of a  13 c { 1 h} rf probe for monitoring the in vivo metabolism of [1‐ 13 c] glucose in primate brain | Zendy

Hammer B. E. | Zendy; Sacks W. | Zendy; Bigler R. E. | Zendy; Hennessy M. J. | Zendy; Sacks S. | Zendy; Fleischer A. | Zendy; Zanzonico P. B | Zendy

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Design of a 13 c { 1 h} rf probe for monitoring the in vivo metabolism of [1‐ 13 c] glucose in primate brain

Author(s) -

Hammer B. E.,

Sacks W.,

Bigler R. E.,

Hennessy M. J.,

Sacks S.,

Fleischer A.,

Zanzonico P. B

Publication year - 1990

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910130102

Subject(s) - in vivo , glutamine , nuclear magnetic resonance , bolus (digestion) , metabolism , glutamate receptor , chemistry , biology , biochemistry , physics , amino acid , anatomy , receptor , microbiology and biotechnology

The design of an RF probe suitable for obtaining proton‐decoupled 13 C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of 13 C and the other to the resonant frequency of 1 H, were used to monitor the in vivo metabolism of [1‐ 13 C] glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of 13 C‐enriched glutamate and glutamine 30 to 40 min after a bolus injection of [ 1‐ 13 C] glucose.

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