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Design of a 13 c { 1 h} rf probe for monitoring the in vivo metabolism of [1‐ 13 c] glucose in primate brain
Author(s) -
Hammer B. E.,
Sacks W.,
Bigler R. E.,
Hennessy M. J.,
Sacks S.,
Fleischer A.,
Zanzonico P. B
Publication year - 1990
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910130102
Subject(s) - in vivo , glutamine , nuclear magnetic resonance , bolus (digestion) , metabolism , glutamate receptor , chemistry , biology , biochemistry , physics , amino acid , anatomy , receptor , microbiology and biotechnology
The design of an RF probe suitable for obtaining proton‐decoupled 13 C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of 13 C and the other to the resonant frequency of 1 H, were used to monitor the in vivo metabolism of [1‐ 13 C] glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of 13 C‐enriched glutamate and glutamine 30 to 40 min after a bolus injection of [ 1‐ 13 C] glucose.