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Studies of the metabolism of human breast cancer spheroids by NMR
Author(s) -
Ronen S.,
Degani H.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910120217
Subject(s) - spheroid , metabolism , in vivo , metabolite , breast cancer , function (biology) , chemistry , nuclear magnetic resonance spectroscopy , in vitro , nuclear magnetic resonance , cancer , biology , biochemistry , microbiology and biotechnology , stereochemistry , physics , genetics
Abstract Spheroids present a model for tumor behavior in vivo . In NMR studies, a problem of spheroid adhesion occurs. Here, we present a method which overcomes this problem and show the variations in phosphate metabolite concentrations as well as the rate of glucose metabolism as a function of spheroid age. © 1989 Academic Press, Inc.