Premium
Monoclonal antibody‐coated magnetite particles as contrast agents in magnetic resonance imaging of tumors
Author(s) -
Cerdan Sebastian,
Lötscher Hans Ruedi,
Künnecke Basil,
Seelig Joachim
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910120202
Subject(s) - magnetite , monoclonal antibody , magnetic resonance imaging , contrast (vision) , nuclear magnetic resonance , contrast effect , materials science , magnetite nanoparticles , magnetic nanoparticles , chemistry , antibody , nanoparticle , nanotechnology , medicine , radiology , immunology , physics , optics , metallurgy
A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe 3 O 4 ) particles with monoclonal antibodies directed against a tumor antigen. The preparation maintains both the immunoreactivity of the monoclonal antibody and the full relaxing capability of the magnetite particle. MRI image contrast by spin‐echo methods can be easily induced in a concentration range of 1–10 n M of the antibody‐coated magnetite particles. © 1989 Academic Press, Inc.