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The effect of gadolinium DTPA on tissue water compartments in slow‐ and fast‐twitch rabbit muscles
Author(s) -
Kofi Adzamli I.,
Jolesz Ferenc A.,
Bleier Alan R.,
Mulkern Robert V.,
Sandor Tamas
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910110205
Subject(s) - chemistry , skeletal muscle , extracellular , perfusion , gadolinium , lagomorpha , nuclear magnetic resonance , anatomy , biophysics , medicine , biochemistry , biology , physics , organic chemistry
Abstract Proton T2 relaxation and its biexponential components have been determined in rabbit skeletal muscle in the presence and absence of GdDTPA. The effect of GdDTPA, which distributes only in the extracellular space, was greatest in the longer‐relaxing T2 component (T2 2 ). A 27% reduction in T2 2 was measured for slow‐twitch (red) muscle and 17% for fast‐twitch (white) muscle, consistent with the larger extracellular space of the former. Magnetic resonance images demonstrated apparent contrast between red and white rabbit muscles. This contrast was instantaneously enhanced by administration of GdDTPA and returned to near normal levels after approximately 30 min. These functional changes in tissue contrast are consistent with differences in blood perfusion and biological water compartmentation between fast‐ and slow‐twitch skeletal muscles.