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Androgen sensitivity of rat prostate carcinoma studied by 31 P NMR spectroscopy, 1 H MR imaging, and 23 Na MR imaging
Author(s) -
Vigneron D. B.,
Hricak H.,
James T. L.,
Jajodia P. B.,
Nunes L.,
Narayans P.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910110203
Subject(s) - androgen , prostate cancer , prostate , hormone , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , androgen deprivation therapy , endocrinology , in vivo magnetic resonance spectroscopy , medicine , chemistry , cancer , radiology , organic chemistry
Abstract 31 P NMR spectroscopy, 1 H magnetic resonance (MR) imaging, and 23 Na MR imaging were used to study the biochemical difference between nine hormone‐sensitive and six hormone‐resistant rat prostate cancers and to follow bioenergetic and morphologic changes subsequent to androgen deprivation in the hormone‐sensitive model. Neither 1 H nor 23 Na MR image characteristics were useful in distinguishing androgen‐sensitive from androgen‐resistant prostate cancer nor in identifying androgen deprivation. 31 P NMR spectroscopy did detect bioenergetic differences between the hormone‐sensitive and hormone‐resistant tumors. Baseline spectra showed a significantly higher PCr/ATP ratio (mean 0.86 ± 0.09 SEM) for hormone‐sensitive tumors than for hormone‐resistant tumors (mean 0.26 ± 0.07 SEM). By 3 days after androgen deprivation (orchiectomy (castration)), PCr/ATP ratios had decreased noticeably; by 1 week, the decrease was statistically significant and remained so for the rest of the study (3 weeks). It appears that 31 P NMR spectroscopy is useful in detecting androgen sensitivity of prostatic carcinoma. © 1989 Academic Press, Inc.