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In vivo localized ESR spectroscopy reflecting metabolism
Author(s) -
Bacic G.,
Nilges M. J.,
Magin R. L.,
Walczak T.,
Swartz H. M.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910100211
Subject(s) - in vivo , chemistry , spectroscopy , electron paramagnetic resonance , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , metabolism , redox , oxygen , biophysics , biochemistry , inorganic chemistry , stereochemistry , biology , physics , microbiology and biotechnology , quantum mechanics , organic chemistry
Localized electron spin resonance spectroscopy in Live mice was performed using a surface coil operating at 1.1 GHz with sufficient sensitivity and stability to measure quantitatively the time course of the distribution, uptake, and reduction of nitroxides in selected organsfregions (liver, bladder, head) of mice. The ability to measure regional concentrations of nitroxides in vivo could be used for pharmacokinetic analysis of drugs labeled with nitroxides and for measurement of oxygen concentrations and redox metabolism. © 1989 Academic Press, Inc.