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MRI detection of myocardial perfusion changes by gadolinium‐DTPA infusion during dipyridamole hyperemia
Author(s) -
Miller D. Douglas,
Holmvang Godtfred,
Gill John B.,
Dragotakes Donna,
Kantor Howard L.,
Okada Robert D.,
Brady Thomas J.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910100209
Subject(s) - dipyridamole , gadolinium , perfusion , medicine , blood flow , circumflex , nuclear medicine , bolus (digestion) , magnetic resonance imaging , thallium , perfusion scanning , cardiology , artery , radiology , chemistry , inorganic chemistry , organic chemistry
Abstract To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated ( r 2 = 0.93). © 1989 Academic Press, Inc.