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Magnetic field modulation of receptor binding
Author(s) -
Chiles Catherine,
Hawrot Edward,
Gore John,
Byck Robert
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910100208
Subject(s) - receptor , nuclear magnetic resonance , acetylcholine receptor , biophysics , magnetic field , macromolecule , neurotoxin , acetylcholine , chemistry , neurotransmitter , nicotinic agonist , physics , biology , biochemistry , endocrinology , quantum mechanics
Although it is widely held that the magnetic fields encountered during magnetic resonance imaging (MRI) and other procedures have no discernible effect on biological systems, we find that at early times of incubation, the amount of binding of the neurotoxin, α‐bungarotoxin, to nicotinic acetylcholine receptor is significantly reduced in a constant 2.0‐T magnetic field. This finding suggests that steady magnetic fields can directly affect the functional activity of biologically important macromolecules, in this particular case a neurotransmitter receptor. © 1989 Academic press, Inc.