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Quantitative and qualitative fat analysis in human leg muscle of neuromuscular diseases by 1 H MR spectroscopy in vivo
Author(s) -
Bárány M.,
Venkatasubramanian P. N.,
Mok E.,
Siegel I. M.,
Abraham E.,
Wycliffe N. D.,
Mafee M. F.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910100206
Subject(s) - gastrocnemius muscle , duchenne muscular dystrophy , spinal muscular atrophy , anatomy , chemistry , atrophy , medicine , nuclear magnetic resonance , skeletal muscle , physics , disease
1 H MR spectra were recorded from human gastrocnemius muscle at 63.86 MHz using the body coil of the Signa scanner as transmitter and a 3‐in. surface coil as receiver. The fat content of the muscle was quantified relative to that of water in a selected volume or slice. The fat/water ratio was 0.05−0.07 for normal muscle but increased to 0.5−6.0 in primary and secondary muscular disorders such as Duchenne and myotonic dystrophy, Charcot‐Marie‐Tooth and polio muscular atrophy, cerebral palsy, and spina bifida. In Werdnig‐Hoffmann spinal atrophy the ratio was above 10. Water‐suppressed and sliceselective 1 H spectroscopy was used for qualitative analysis of fat. The 1 H profile of gastrocnemius muscles between healthy individuals and patients with neuromuscular diseases showed two major differences. In the normal muscle spectra, the resonance from the –(CH 2 ) n – protons at 1.6 ppm was the most pronounced, whereas in the diseased muscle spectra resonances also appeared between 1.1 and 1.4 ppm. Some diseased muscle spectra showed multiple resonances from CHCH– in polyunsaturated fatty acids between 5.5 and 7.0 ppm. The corresponding resonances from CH‐CH 2 –, 1.9−2.0 ppm, and CH‐CH 2 ‐CH, 2.7−2.9 ppm, were also seen. These peaks are usually not detected in normal muscle. © 1989 Academic Press, Inc.