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A method for direct in vivo measurement of drug concentrations from a single 2 H NMR spectrum
Author(s) -
Evelhoch Jeffrey L.,
McCoy Cheryl L.,
Giri Brij P.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910090313
Subject(s) - in vivo , nuclear magnetic resonance , chemistry , proton nmr , drug , nuclear magnetic resonance spectroscopy , deuterium , detection limit , analytical chemistry (journal) , chromatography , physics , nuclear physics , pharmacology , medicine , biology , microbiology and biotechnology
Abstract The use of 2 H‐labeled drugs provides a measure of drug concentration in situ directly from a single 2 H NMR spectrum obtained with any antenna by correcting only for differential saturation effects. The limit of detection for a drug labeled with three equivalent deuterons is roughly 0.5 mM. © 1989 Academic Press, Inc.