A method for direct  in vivo  measurement of drug concentrations from a single  2 H NMR spectrum | Zendy

Evelhoch Jeffrey L. | Zendy; McCoy Cheryl L. | Zendy; Giri Brij P. | Zendy

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A method for direct in vivo measurement of drug concentrations from a single 2 H NMR spectrum

Author(s) -

Evelhoch Jeffrey L.,

McCoy Cheryl L.,

Giri Brij P.

Publication year - 1989

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910090313

Subject(s) - in vivo , nuclear magnetic resonance , chemistry , proton nmr , drug , nuclear magnetic resonance spectroscopy , deuterium , detection limit , analytical chemistry (journal) , chromatography , physics , nuclear physics , pharmacology , medicine , biology , microbiology and biotechnology

The use of 2 H‐labeled drugs provides a measure of drug concentration in situ directly from a single 2 H NMR spectrum obtained with any antenna by correcting only for differential saturation effects. The limit of detection for a drug labeled with three equivalent deuterons is roughly 0.5 mM. © 1989 Academic Press, Inc.

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