Premium
In vivo high‐resolution volume‐selected proton spectroscopy and T 1 measurements in the dog brain
Author(s) -
Galloway Graham J.,
Field James,
Rose Stephen E.,
Haseler Luke J.,
Brooks William M.,
Brereton Ian M.,
Bore Peter J.,
Crozier Stuart,
Doddrell David M.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910090215
Subject(s) - nuclear magnetic resonance , in vivo , volume (thermodynamics) , resolution (logic) , proton , spectroscopy , high resolution , nuclear magnetic resonance spectroscopy , in vivo magnetic resonance spectroscopy , chemistry , nuclear medicine , physics , biology , medicine , magnetic resonance imaging , nuclear physics , computer science , geology , remote sensing , artificial intelligence , radiology , microbiology and biotechnology , quantum mechanics
Successful in vivo NMR spectroscopy requires a combination of techniques to address the problems of volume selection, water suppression, and resolution. All this needs to be done in the very heterogeneous environment found in living organisms. Previously published techniques are used to obtain 1 H spectra from a dog brain, observing metabolites with concentrations below 1 m M . Measurements of spin‐lattice relaxation times ( T 1 ) are also presented. The 1 H relaxation times are long ( T 1 > 1.0 s) yielding information about the fluidity of the molecular environment. Comments are made concerning the achievable linewidth in vivo and the deficiencies that phase‐encoding spectroscopic methods may have in obtaining high‐resolution 1 H spectra. © 1989 Academic Press, Inc.