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The unequivocal determination of lactic acid using a one‐ dimensional zero‐quantum coherence‐transfer technique
Author(s) -
Doddrell David M.,
Brereton Ian M.,
Moxon Leith N.,
Galloway Graham J.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910090116
Subject(s) - coherence (philosophical gambling strategy) , acetaldehyde , excitation , zero (linguistics) , gaussian , quantum , chemistry , limiting , nuclear magnetic resonance , atomic physics , physics , analytical chemistry (journal) , quantum mechanics , chromatography , linguistics , philosophy , organic chemistry , ethanol , mechanical engineering , engineering
Abstract A method based on zero‐quantum coherence transfer for spectral editing of metabolites in aqueous solution in a one‐dimensional experiment is described. Water suppression factors of approximately 8000 were achieved by the use of pulsed B 0 field gradients and excellent editing was obtained in a single acquisition. The methyl resonances of both lactate and acetaldehyde were readily observed in a mouse brain homogenate by generat‐ ing zero‐quantum coherence using Gaussian pulses for selective excitation of the respective CH resonances. © 1989 Academic Press, Inc.