Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy | Zendy

Bruhn H. | Zendy; Frahm J. | Zendy; Gyngell M. L. | Zendy; Merboldt K. D. | Zendy; Hänicke W. | Zendy; Sauter R. | Zendy

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Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy

Author(s) -

Bruhn H.,

Frahm J.,

Gyngell M. L.,

Merboldt K. D.,

Hänicke W.,

Sauter R.

Publication year - 1989

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910090115

Subject(s) - nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , stroke (engine) , metabolism , spectroscopy , acute stroke , proton , functional magnetic resonance spectroscopy of the brain , chemistry , medicine , magnetic resonance imaging , physics , radiology , nuclear physics , quantum mechanics , tissue plasminogen activator , thermodynamics

Localized proton NMR spectroscopy at 1.5 T using stimulated echoes has been applied to study metabolic alterations in the postischemic phase of patients with acute cerebral infarction. A complete depletion of N ‐acetyl aspartate in the area of infarction has been observed in a patient studied 4 days after stroke. This finding was paralleled by a dramatic increase in the concentration of lactic acid to about 16 m M within the lesion, indicating continued anaerobic glycolysis. The diluting effect of the edema has been estimated to reduce average metabolite concentrations by about a factor of 3. © 1989 Academic Press, Inc.

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