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Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy
Author(s) -
Bruhn H.,
Frahm J.,
Gyngell M. L.,
Merboldt K. D.,
Hänicke W.,
Sauter R.
Publication year - 1989
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910090115
Subject(s) - nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , stroke (engine) , metabolism , spectroscopy , acute stroke , proton , functional magnetic resonance spectroscopy of the brain , chemistry , medicine , magnetic resonance imaging , physics , radiology , nuclear physics , quantum mechanics , tissue plasminogen activator , thermodynamics
Localized proton NMR spectroscopy at 1.5 T using stimulated echoes has been applied to study metabolic alterations in the postischemic phase of patients with acute cerebral infarction. A complete depletion of N ‐acetyl aspartate in the area of infarction has been observed in a patient studied 4 days after stroke. This finding was paralleled by a dramatic increase in the concentration of lactic acid to about 16 m M within the lesion, indicating continued anaerobic glycolysis. The diluting effect of the edema has been estimated to reduce average metabolite concentrations by about a factor of 3. © 1989 Academic Press, Inc.