Boron‐11 MRI and MRS of intact animals infused with a boron neutron capture agent | Zendy

Kabalka George W. | Zendy; Davis Mark | Zendy; Bendel Peter | Zendy

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Boron‐11 MRI and MRS of intact animals infused with a boron neutron capture agent

Author(s) -

Kabalka George W.,

Davis Mark,

Bendel Peter

Publication year - 1988

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910080214

Subject(s) - boron , neutron capture , radiochemistry , in vivo , gadolinium , chemistry , imaging agent , nuclear magnetic resonance , materials science , nuclear chemistry , nuclear medicine , medicine , physics , organic chemistry , microbiology and biotechnology , biology

Boron neutron capture therapy (BNCT) depends on the delivery of boron‐containing drugs to a targeted lesion. Currently, the verification and quantification of in vivo boron content is a difficult problem. Boron‐11 spectroscopy was utilized to confirm the presence of a dimeric sulfhydryl dodecaborane BNCT agent contained in an intact animal. Spectroscopy experiments revealed that the decay time of transverse magnetization of the boron‐11 spins was less than 1 ms which precluded the use of a 2DFT imaging protocol. A back‐projection protocol was developed and utilized to generate the first boron‐11 image of a BNCT agent in the liver of an intact Fisher 344 rat. © 1988 Academic Press, Inc.

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