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In Vivo 13 C NMR Spectroscopy of the Human Prostate
Author(s) -
Sillerud Laurel O.,
Halliday Karen R.,
Griffey Richard H.,
FenoglioPreiser Cecilia,
Sheppardy Scott
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910080213
Subject(s) - prostate , in vivo , nuclear magnetic resonance spectroscopy , chemistry , nuclear magnetic resonance , biology , medicine , stereochemistry , physics , microbiology and biotechnology , cancer
The metabolism of the normal and hyperplastic human and rat prostate differs from that of other tissues in that this organ supports and secretes high concentrations of citrate. During the dedifferentiation process that is characteristic of neoplasia, the ability of the prostate to maintain these high citrate levels is markedly diminished. We undertook a natural abundance 13 C NMR study of the human and rat prostate in vitro and the human organ in vivo in order to determine whether the amounts of citrate in the nonmalignant prostate were sufficiently high to be detected. We report here our success at detecting citrate via 13 C NMR in all three of these systems. © 1988 Academic Press, Inc.