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Integrated volume‐selective/spectral editing 1 H NMR and postdetection signal processing for the sensitive determination of lactate
Author(s) -
Knüttel A.,
Rommel E.,
Clausen M.,
Kimmich R.
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910080108
Subject(s) - heteronuclear molecule , pulse sequence , decoupling (probability) , chemistry , signal (programming language) , pulse (music) , nuclear magnetic resonance , volume (thermodynamics) , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , chromatography , computer science , physics , optics , quantum mechanics , control engineering , detector , engineering , programming language
A new volume selection/spectral editing pulse sequence (VOSING) is presented. The features specific to the technique are that the volume selection and the editing intervals coincide and that no decoupling is necessary. The pulse sequence can be applied under both homo‐ and heteronuclear conditions. Phantom experiments with lactate solutions and human serum led to water suppression factors of about 20,000. A postdetection signal processing method has been implemented. The final sensitivity for lactate determinations could thus be improved by a factor of more than 4. Ischemia‐induced lactate could easily be detected in serum. At present, the lower detection limit of lactate is 1 mmol/liter for a(1.2cm) 3 voxel and 32 scans in a 4.7‐T/40‐cmmagnet. © 1988 Academic Press, Inc.