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Deuterium NMR cerebral imaging in Situ
Author(s) -
Ewy Coleen S.,
Ackerman Joseph J. H.,
Balaban Robert S.
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910080105
Subject(s) - deuterium , nuclear magnetic resonance , relaxation (psychology) , spin–lattice relaxation , chemistry , magnetic resonance imaging , nuclide , spin–spin relaxation , physics , nuclear physics , medicine , radiology , nuclear quadrupole resonance
Nuclear magnetic resonance imaging of deuterium is demonstrated in cat brain in vivo and in situ at 4.7 T magnetic field strength. Images were acquired at 4–5% deuterium enrichment, using D 2 O as a nuclear spin label, with as little as 10‐s time resolution. This suggests the potential application of D 2 O as an exogenous MRI label for quantitative flow imaging or contrast enhancement. The efficient quadrupolar relaxation mechanism of the deuterium nuclide results in a short ca. 250 ms spin–lattice relaxation time ( T 1 ). This allows for rapid signal averaging, thus increasing signal‐to‐noise in the deuterium image. Additionally, three widely dispersed deuterium spin–spin relaxation times ( T 2 ) are observed of ca. 10, 40, and 400 ms which provide high compartmental image contrast, thus yielding information of physiological as well as anatomical interest. T 2 ‐weighted deuterium cerebral images are presented showing marked tissue relaxation discrimination. © 1988 Academic Press, Inc.