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Water proton NMR relaxation mechanisms in lung tissue
Author(s) -
Kveder M.,
Zupančič I.,
Lahajnar G.,
Blinc R.,
Šuput D.,
Ailion D. C.,
Ganesan K.,
Goodrich C.
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910070406
Subject(s) - relaxation (psychology) , larmor precession , spin–lattice relaxation , nuclear magnetic resonance , transpulmonary pressure , chemistry , proton , nuclear magnetic resonance spectroscopy , free water , lung , materials science , magnetic field , physics , lung volumes , nuclear physics , medicine , quantum mechanics , environmental engineering , engineering , nuclear quadrupole resonance
The NMR relaxation times T 2 , T 2 , and T 1 were measured in isolated rat lungs as functions of external magnetic field B 0 , temperature, and lung inflation. The observed linear dependence on B 0 of the tissue‐induced free induction decay rate ( T 2 ) −1 provides independent confirmation of the air/water interface model of the lung. Furthermore, measurements of the Larmor frequency dependence of T 1 , are consistent with a spin‐lattice relaxation rate of the form 1/T l = A ω −1/2 + B as expected for the case in which the relaxation arises from water‐biopolymer cross‐relaxation, which should be proportional to the surface area of the lung. This prediction was verified by observations of an approximately linear dependence of 1/T 1 , on transpulmonary pressure and thus on the lung surface area. © 1988 Academic Press, Inc.