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Paramagnetic contrast enhancement at 0.02 T: An experimental study using Gd‐DOTA in normal and hydronephrotic kidneys
Author(s) -
Niemi Pekka,
Paajanen Hannu,
Määttänen Heli,
Komu Markku,
Erkintalo Minna,
Alanen Anu,
Dean Peter B.,
Kormano Martti
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910070308
Subject(s) - hydronephrosis , contrast enhancement , renal cortex , nuclear medicine , chemistry , kidney , dota , renal medulla , magnetic resonance imaging , renal pelvis , medulla , nuclear magnetic resonance , medicine , urology , endocrinology , radiology , urinary system , physics , chelation , organic chemistry
Both normal and experimentally hydronephrotic rabbits were imaged at 0.02 T using partial saturation (PS 160/30) and inversion recovery (IR 1000/200/40) sequences. The signal intensity of normal renal medulla and cortex markedly increased after the injection of 0.1 mmol/kg of Gd‐DOTA. In the unilateral total hydronephrosis the dilated renal pelvis did not contrast enhance after 15 and 35 min of Gd‐DOTA injection. The enhancement pattern was similar in 1‐ and 3‐week‐old hydronephrosis. The effect of Gd‐DOTA on renal T1 times at 0.02 T was studied using rats. Fifteen minutes after the Gd‐DOTA injection (0.1 mmol/kg) the TI times of excised rat kidneys decreased from 311 to 90 ms. The authors conclude that the enhancement of the MR signal of the kidney by Gd‐DOTA at an ultralow magnetic field (0.02 T) is similar to its enhancement at higher fieldss (>0.15 T). © 1988 Academic Press, Inc.