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Renal imaging studies at 1.5 and 9.4 T: Effects of diuretics
Author(s) -
Sarkar Susanta K.,
Holland George A.,
Lenkinski Robert E.,
Mattingly Mark A.,
Kinter Lewis B.
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910070114
Subject(s) - furosemide , vasopressin , antagonist , kidney , medullary cavity , vasopressin antagonists , medicine , endocrinology , diuretic , chemistry , receptor
Abstract We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosmide completely dissipates the cortical‐inner medullary T 2 gradient whereas the vasopressin antagonist has little effect. This phenomenon appears to be related to changes in luminal water content. We also demonstrate the feasibility of obtaining live mouse kidney images with a resolution of 100 × 100 × 700 μm at 9.4 T. © 1988 Academic Press, Inc.