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The application of depth‐pulse localized 31 P NMR spectroscopy to monitor tumor metabolism and response to chemotherapy in the rat kidney
Author(s) -
Stewart C. A.,
Hanstock C. C.,
Allen P. S.
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910070112
Subject(s) - infiltration (hvac) , metabolism , kidney , cyclophosphamide , chemistry , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , chemotherapy , energy metabolism , pulse (music) , cancer research , pathology , medicine , materials science , physics , biochemistry , optics , detector , composite material
To illustrate the spatial variations in metabolism within tumors, 31 P spectral data are presented from a predefined, depth‐pulse localized region of a rat kidney impregnated with Walker sarcoma cells. These data display the changes in energy metabolism during infiltration of the kidney by the tumor and during treatment of the tumor with cyclophosphamide. © 1988 Academic Press, Inc.