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An experimental approach to 31 P spin–lattice relaxation time measurement in biological systems
Author(s) -
Seo Yoshiteru,
Murakami Masataka,
Suzuki Eiji,
Maeda Munehiko,
Watari Hiroshi
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910060408
Subject(s) - phosphate , creatine , chemistry , saliva , spin–lattice relaxation , glycolysis , nuclear magnetic resonance , metabolism , biochemistry , physics , nuclear quadrupole resonance
The accuracy of measurement of the spin‐lattice relaxation time ( T 1 ) in biological systems using the variable nutation angle method is discussed using computer simulations. This method could reduce the time required for measurement to 10% of that using the inversion recovery method. In the perfused salivary gland of the rat (310 K), the T 1 values of sugar phosphates, creatine phosphate, γ‐phosphate, and β‐phosphate of nucleotide triphosphates determined by this method were 5.2, 4.8, 0.9, and 0.8 s, respectively. During secretion of saliva, the T 1 value of sugar phosphates decreased to 3.7 s, which could be due to an increased chemical exchange of phosphate in glycolysis. © 1988 Academic Press, Inc.