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Sodium NMR imaging of lung water in rats
Author(s) -
Kundel Harold L.,
Shetty Anil,
Joseph Peter M.,
Summers Ronald M.,
Kassab Eleanor A.,
Moore Bethanne
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910060403
Subject(s) - edema , sodium , chemistry , lung , saline , nuclear magnetic resonance , nuclear medicine , medicine , anesthesia , physics , organic chemistry
Coronal proton and sodium images of control rats and rats with either increased permeability edema produced by intravenous alloxan (300 mg/kg) or increased pressure edema produced by saline infusion (2 ml/min) were obtained. Axial chest CT images were used to monitor the development of pulmonary edema. Immediately after the imaging session compartmental lung water was measured gravimetrically. The sodium and proton imaging were done sequentially in a 31‐cm‐bore 1.9‐T magnet without moving the animal. The anatomical boundaries of the lung on the proton images were transferred to the sodium images for calculation of the average sodium signal intensity which was determined by extrapolating the mean values from five echoes to time zero. The sodium signal intensity was correlated ( r = 0.7) with the total water fraction. There was poor correlation ( r = 0.56) with the extravascular water due to confounding by the sodium vascular signal. © 1988 Academic Press, Inc.