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Experimental acute pancreatitis: MR relaxation time studies using gadolinium–DTPA
Author(s) -
Paajanen Hannu,
Brasch Robert C.,
Dean Peter B.
Publication year - 1988
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910060107
Subject(s) - pancreas , pancreatitis , in vivo , edema , gadolinium , magnetic resonance imaging , medicine , acute pancreatitis , relaxometry , pathology , chemistry , nuclear medicine , spin–lattice relaxation , nuclear magnetic resonance , spin echo , radiology , biology , physics , microbiology and biotechnology , organic chemistry , nuclear quadrupole resonance
Spin–lattice (T1) and spin–spin (T2) relaxation times of normal and sodium taurocholate‐induced pancreatitis (38 rats) were determined in vitro using a 10.7‐MHz magnetic resonance (MR) spectrometer. The increase in pancreatic T1 time in acute hemorrhagic pancreatitis correlated well with the elevated water content of the organ. Gadolinium–DTPA did not affect significantly the relaxation times of normal pancreas in vitro during 1 to 20 min postinjection, but it decreased the elevated TI times of inflamed pancreas almost to baseline values. MR imaging studies of rat pancreas in vivo (8 rats, 0.35‐T resistive magnet) indicated that the swollen pancreas and associated edema were depicted using a T2‐weighted SE sequence. Fifteen minutes postinjection of gadolinium–DTPA a homogeneous enhancement of inflamed pancreas was detected. The differentiation of pancreatic necrotic foci from surrounding viable tissue and edema could not be detected on Gd–DTPA‐enhanced MR images after 15 min postinjection although microscopical workup indicated these different tissue constituents in the pancreas. © 1988 Academic Press, Inc.