Measurement of lactate accumulation by  in Vivo  proton NMR spectroscopy during global cerebral ischemia in rats | Zendy

Richards T. L. | Zendy; Keniry M. A. | Zendy; Weinstein P. R. | Zendy; Pereira B. M. | Zendy; Andrews B. T. | Zendy; Murphy E. J. | Zendy; James T. L. | Zendy

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Measurement of lactate accumulation by in Vivo proton NMR spectroscopy during global cerebral ischemia in rats

Author(s) -

Richards T. L.,

Keniry M. A.,

Weinstein P. R.,

Pereira B. M.,

Andrews B. T.,

Murphy E. J.,

James T. L.

Publication year - 1987

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910050406

Subject(s) - ischemia , in vivo , nuclear magnetic resonance spectroscopy , chemistry , brain ischemia , medicine , biology , stereochemistry , microbiology and biotechnology

In vivo 1 H NMR spectral editing techniques were used to monitor cerebral lactate production during remotely controlled temporary forebrain ischemia in rats. The lactate/ N ‐acetylaspartate (NAA) ratio correlated with survival after ischemia and subsequent reperfusion. The lactate/NAA ratio that predicted death after ischemia in rats was estimated to be approximately 1.3. © 1987 Academic Press, Inc.

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