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Measurement of lactate accumulation by in Vivo proton NMR spectroscopy during global cerebral ischemia in rats
Author(s) -
Richards T. L.,
Keniry M. A.,
Weinstein P. R.,
Pereira B. M.,
Andrews B. T.,
Murphy E. J.,
James T. L.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910050406
Subject(s) - ischemia , in vivo , nuclear magnetic resonance spectroscopy , chemistry , brain ischemia , medicine , biology , stereochemistry , microbiology and biotechnology
In vivo 1 H NMR spectral editing techniques were used to monitor cerebral lactate production during remotely controlled temporary forebrain ischemia in rats. The lactate/ N ‐acetylaspartate (NAA) ratio correlated with survival after ischemia and subsequent reperfusion. The lactate/NAA ratio that predicted death after ischemia in rats was estimated to be approximately 1.3. © 1987 Academic Press, Inc.