Tumor imaging with anti‐CEA antibody labeled  19 F emulsion | Zendy

Shimizu Masahiro | Zendy; Kobayashi Tetsuro | Zendy; Morimoto Hideki | Zendy; Matsuura Nariaki | Zendy; Shimano Takashi | Zendy; Nomura Nobuhiko | Zendy; Itoh Souichi | Zendy; Yamazaki Masaru | Zendy; Iriguchi Norio | Zendy; Yamamoto Tohru | Zendy; Yamai Satoshi | Zendy; Furuta Tadaaki | Zendy; Maki Takeshi | Zendy; Mori Takesada | Zendy

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Tumor imaging with anti‐CEA antibody labeled 19 F emulsion

Author(s) -

Shimizu Masahiro,

Kobayashi Tetsuro,

Morimoto Hideki,

Matsuura Nariaki,

Shimano Takashi,

Nomura Nobuhiko,

Itoh Souichi,

Yamazaki Masaru,

Iriguchi Norio,

Yamamoto Tohru,

Yamai Satoshi,

Furuta Tadaaki,

Maki Takeshi,

Mori Takesada

Publication year - 1987

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910050311

Subject(s) - antibody , medicine , emulsion , nuclear medicine , chemistry , immunology , biochemistry

The possibility of using 19 MRI for detection of tumors using a 2‐T NMR system was examined in animals. Anticarcino‐embryonic antigen (CEA) antibody conjugated with perfluorochemical (perfluorotributylamine, FTBA) was administered to nude mouse inoculated with LOVO, a CEA‐producing human cancer cell line. Tumor imaging based on the 19 F NMR was examined after excision of the tumors from nude mice ( ex vivo ). The imaging pattern of the tumor coincided with the antibody distribution determined immunohistologically. © 1987 Academic Press, Inc.

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