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Tumor imaging with anti‐CEA antibody labeled 19 F emulsion
Author(s) -
Shimizu Masahiro,
Kobayashi Tetsuro,
Morimoto Hideki,
Matsuura Nariaki,
Shimano Takashi,
Nomura Nobuhiko,
Itoh Souichi,
Yamazaki Masaru,
Iriguchi Norio,
Yamamoto Tohru,
Yamai Satoshi,
Furuta Tadaaki,
Maki Takeshi,
Mori Takesada
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910050311
Subject(s) - antibody , medicine , emulsion , nuclear medicine , chemistry , immunology , biochemistry
The possibility of using 19 MRI for detection of tumors using a 2‐T NMR system was examined in animals. Anticarcino‐embryonic antigen (CEA) antibody conjugated with perfluorochemical (perfluorotributylamine, FTBA) was administered to nude mouse inoculated with LOVO, a CEA‐producing human cancer cell line. Tumor imaging based on the 19 F NMR was examined after excision of the tumors from nude mice ( ex vivo ). The imaging pattern of the tumor coincided with the antibody distribution determined immunohistologically. © 1987 Academic Press, Inc.