Premium
1 H NMR relaxation measurements of human tissues in situ by spatially resolved spectroscopy
Author(s) -
Luyten Peter R.,
Anderson Charles M.,
den Hollander Jan A.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040504
Subject(s) - relaxation (psychology) , nuclear magnetic resonance , chemistry , spectroscopy , in situ , nuclear magnetic resonance spectroscopy , adipose tissue , spin–lattice relaxation , spin–spin relaxation , spectral line , proton , analytical chemistry (journal) , physics , psychology , social psychology , biochemistry , organic chemistry , quantum mechanics , chromatography , nuclear quadrupole resonance , astronomy
Spatially resolved spectroscopy (SPARS) is a method for obtaining high‐resolution NMR spectra of well‐defined volumes of human tissues in situ . This method was combined with the Carr‐Purcell‐Meiboom‐Gill multiple‐echo sequence for T 2 , and with inversion recovery for T 1 relaxation measurements. Relaxation times obtained by SPARS were compared with standard CPMG and IR relaxation measurements and with imaging methods, using a number of relaxation phantoms. Spectroscopically resolved relaxation data of human bone marrow, muscle, and adipose tissue in situ were obtained. T 2 measurements of human adipose tissue gave different results when using single‐echo measurements rather than the CPMG method. This difference was interpreted as a J modulation effect, which shows up in fatty acid proton resonances. This J modulation effect influences the intensity of adipose tissue in routine 1 H NMR images. © 1987 Academic Press, Inc.