Oxygen‐17 compounds as potential NMR  T 2   contrast agents: Enrichment effects of H 2  17 O on protein solutions and living tissues | Zendy

Hopkins A. L. | Zendy; Barr R. G. | Zendy

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Oxygen‐17 compounds as potential NMR T 2 contrast agents: Enrichment effects of H 2 17 O on protein solutions and living tissues

Author(s) -

Hopkins A. L.,

Barr R. G.

Publication year - 1987

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910040413

Subject(s) - oxygen , chemistry , relaxation (psychology) , nuclear magnetic resonance , oxygen 17 , proton , analytical chemistry (journal) , chromatography , organic chemistry , physics , biology , quantum mechanics , neuroscience

The isotopic enrichment of solutions, living tissues, and organisms with oxygen‐17 in the form of H 2 17 O shortens their proton NMR transverse relaxation times ( T 2 ) and produces changes in NMR image intensity. The transverse relaxation rate (1/ T 2 ) was found to be linearly dependent on the H 2 17 O concentration in biological solutions up to 5% enrichment. The longitudinal relaxation time ( T 1 ) is not affected by enrichment. Equal concentrations of H 2 17 O do not produce the same magnitude of T 1 change in all physiological environments. The reasons for these differences are discussed. The results suggest that certain oxygen‐17 compounds should be explored as “contrast agents” in magnetic resonance imaging. © 1987 Academic Press, Inc.

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