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Oxygen‐17 compounds as potential NMR T 2 contrast agents: Enrichment effects of H 2 17 O on protein solutions and living tissues
Author(s) -
Hopkins A. L.,
Barr R. G.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040413
Subject(s) - oxygen , chemistry , relaxation (psychology) , nuclear magnetic resonance , oxygen 17 , proton , analytical chemistry (journal) , chromatography , organic chemistry , physics , biology , quantum mechanics , neuroscience
The isotopic enrichment of solutions, living tissues, and organisms with oxygen‐17 in the form of H 2 17 O shortens their proton NMR transverse relaxation times ( T 2 ) and produces changes in NMR image intensity. The transverse relaxation rate (1/ T 2 ) was found to be linearly dependent on the H 2 17 O concentration in biological solutions up to 5% enrichment. The longitudinal relaxation time ( T 1 ) is not affected by enrichment. Equal concentrations of H 2 17 O do not produce the same magnitude of T 1 change in all physiological environments. The reasons for these differences are discussed. The results suggest that certain oxygen‐17 compounds should be explored as “contrast agents” in magnetic resonance imaging. © 1987 Academic Press, Inc.