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Feasibility study of imaging a living murine tumor by electron paramagnetic resonance
Author(s) -
Berliner Lawrence J.,
Fujii Hirotada,
Wan Xiaoming,
Lukiewicz S. J.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040410
Subject(s) - nuclear magnetic resonance , magnetic resonance imaging , electron paramagnetic resonance , paramagnetism , electron nuclear double resonance , electron paramagnetic resonance spectroscopy , medicine , chemistry , materials science , physics , radiology , condensed matter physics
An electron paramagnetic resonance image was measured for the first time from in vivo field gradient spectra of a living murine tumor (Cloudman S‐91 melanoma in the tail of a DBA‐2J mouse) using the paramagnetic nitroxide imaging agent 3‐carboxamido‐2,2,5,5‐tetramethylpyrroline‐l‐oxyl injected into the tail vein. The experiments were accomplished at L‐band frequency (1.55 GHz) with a single‐turn flat‐loop coil. A cross‐sectional image was obtained perpendicular to the tail axis, which clearly distinguished features to the submillimeter resolution level. © 1987 Academic Press, Inc.