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In vivo 31 P NMR spectroscopy of agonist‐stimulated phosphatidylinositol metabolism in cat brain
Author(s) -
Renshaw Perry F.,
Schnall Mitchell D.,
Leigh John S.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040303
Subject(s) - phosphatidylinositol , inositol , in vivo , inositol phosphate , chemistry , metabolism , agonist , nuclear magnetic resonance spectroscopy , phosphate , biochemistry , receptor , biology , stereochemistry , signal transduction , microbiology and biotechnology
As a result of the agonist stimulation of muscarinic receptors, myc‐inositol‐1 ‐phosphate accumulates in the presence of millimolar lithium concentrations. This accumulation of myo ‐inositol‐1 ‐phosphate can be detected by in vivo 31 P NMR spectroscopy. Since myo ‐inositol‐1‐phosphate is a breakdown product of phosphatidylinositol, this may provide a means of noninvasively monitoring phosphatidylinositol metabolism in vivo . © 1987 Academic Press, Inc.