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In vivo proton spin‐lattice relaxation times of normal and dystrophic muscles
Author(s) -
Narayana P. A.,
Brey W. W.,
Kulkarni M. V.,
Misra L. K.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040208
Subject(s) - nuclear magnetic resonance , in vivo , chemistry , proton , spin–lattice relaxation , anatomy , materials science , physics , medicine , biology , nuclear physics , microbiology and biotechnology , nuclear quadrupole resonance
In vivo spin‐lattice relaxation times ( T 1 ) of water and lipid protons were measured in normal and dystrophic chicken pectoralis muscles at different ages. Values were obtained with a surface coil used as both a receiver and a transmitter. A 2θ‐T 1 ‐θ‐Acquisition sequence was used for these measurments. Accuracy was verified with an inversion‐recovery method using a slotted tube resonator as the transmitter and a surface coil as the receiver. It was observed that (1) the T 1 values of water protons in normal muscles decrease with age, (2) the T 1 values of water protons do not change with age in dystrophic muscles, and (3) the T 1 values of lipid protons increase with age in normal and dystrophic muscles. These results indicate a failure of the normal maturation of dystrophic muscles. © 1987 Academic Press, Inc.